个人简介

       陈忠研，博士，硕士生导师，主要从事有机小分子荧光探针的构筑及生物成像研究。本科和硕士均毕业于beat365官方网站，博士毕业于南京大学化学化工学院，2020至今在温州大学化学与材料科学学院任教。

以一作/通讯作者身份在J. Am. Chem. Soc.、Anal. Chem.、Chem. Commun.、Org. Lett.、Org. Chem. Front.、Chem. Eur. J.等国际期刊发表SCI论文十余篇，申请发明专利8项，授权发明专利4项；主持国家自然科学基金面上项目1项，浙江省自然科学基金、温州市科技局等科研项目多项，参与国家重点研发计划、国家自然科学基金重点项目等研究。曾获“温州市科技创新和人才工作成绩突出个人”等荣誉称号。

承担《无机化学》、《无机化学实验》、《化学生物学》、《普通化学》等专业课教学任务，教学认真负责，其中《无机化学》、《无机化学实验》、《普通化学》等课程获“优课优酬”奖励；指导/协助指导课题组研究生开展研究，部分研究生考入南京大学、中山大学、南开大学、四川大学、内蒙古大学等高校读博深造。

科研项目

[1] 国家自然科学基金面上项目，22477096，2025/01-2028/12，50万，主持

[2] 温州市基础性科研项目，Y20240004，2024/07-2026/06, 9万，主持

[3] 浙江省自然科学基金探索项目，LQ21B050001，2021/01-2023/12，10万，主持

[4] 温州市基础性科研项目，Y20210265，2022/01-2023/12，4万，主持

代表性论文

[16] Weitao Xing, Kaili Yang, Yonglong Zhu, Xinyi Li, Yan Zhang, Linxia Guo, Jing-Yuan Ge*, Yang Bai*, Zhongyan Chen*. Rational design of a near-infrared fluorescent probe for rapid monitoring of carboxylesterase in live cells and drug-induced liver injury mice, Anal. Chim. Acta 2025, 1346, 343782.

文章链接：https://www.sciencedirect.com/science/article/pii/S000326702500176X

[15] Kexin Wang, Ruoxi Wang, Zihui Yan, Yi Li, Yangchen Shi, Jing-Yuan Ge, Yang Bai,* Zhongyan Chen,* Lei Zhang*. Rational Design of a Highly Sensitive Carboxylesterase Probe and Its Application in High-Throughput Screening for Uncovering Carboxylesterase Inhibitors, J. Org. Chem. 2024, 89, 14650–14657.

文章链接：https://pubs.acs.org/doi/10.1021/acs.joc.4c00699

[14] Yi Li, Huilin Sun, Chenxue Yang, Zihui Yan, Jing-Yuan Ge, Jianhao Wang,* Zhongyan Chen,* Lin Qiu, and Yang Bai*. Metal−Organic Frameworks-Based Nanoplatform for Treatment of Breast Cancer, ACS Appl. Nano Mater. 2024, 7, 10532−10542.

文章链接：https://pubs.acs.org/doi/10.1021/acsanm.4c00984

[13] Meng-Qian Yu, Cai-Yi Yang, Lian-Jun Dong, Yong Yan, Yu-Jie Feng, Zhongyan Chen*, Hong-Ping Xiao, Hai-Ying Wang*, Jing-Yuan Ge*. Metal Effect on the Proton Conduction of Three Isostructural Metal–Organic Frameworks and Pseudo-Capacitance Behavior of the Cobalt Analogue, Inorg. Chem. 2024, 63, 19287-19298.

文章链接：https://pubs.acs.org/doi/10.1021/acs.inorgchem.4c02958

[12] Zhi-Lin Mu, Yi-Qing Ma, Yibin Zhu, Zhongyan Chen*, Hong-Ping Xiao, Xinhua Li, Hai-Ying Wang*, Jing-Yuan Ge*. Two Stable Bifunctional Zinc Metal–Organic Frameworks with Luminescence Detection of Antibiotics and Proton Conduction, Inorg. Chem. 2023, 62, 20314–20324.

文章链接：https://pubs.acs.org/doi/10.1021/acs.inorgchem.3c03315

[11] Yaogeng Ma, Min Li, Huilin Sun, Jing-Yuan Ge, * Yang Bai,* Lin Qiu, Xuan Wu,* Jiuxi Chen a and Zhongyan Chen *.Strategic design of an NIR probe for viscosity imaging in inflammatory and non-alcoholic steatohepatitis mice, Chem. Commun., 2023, 59, 14025-14028.

文章链接：https://pubs.rsc.org/en/content/articlelanding/2023/CC/D3CC04041K

[10] Zhongyan Chen, Yuncong Chen*, Yunjian Xu, Xiangchao Shi, Zhong Han, Yang Bai, Hongbao Fang, Weijiang He*, and Zijian Guo*. BODIPY-Based Multifunctional Nanoparticles for Dual Mode Imaging-Guided Tumor Photothermal and Photodynamic Therapy, ACS Appl. Bio Mater. 2023, 6, 3406-3413

文章链接：https://pubs.acs.org/doi/10.1021/acsabm.3c00083

[9] Zhongyan Chen, Xueling Mu, Zhong Han, Shiping Yang*, Changli Zhang, Zijian Guo*, Yang Bai, and Weijiang He*. An Optical/Photoacoustic Dual-Modality Probe: Ratiometric in/ex Vivo Imaging for Stimulated H₂S Upregulation in Mice, J. Am. Chem. Soc., 2019, 141, 45, 17973-17977.

文章链接：https://pubs.acs.org/doi/10.1021/jacs.9b09181

[8] Lepeng Chen, Wenzhang Xiong, Yaogeng Ma, Jing-Yuan Ge,* Ningning Lv, Xuan Wu,* Jiuxi Chen,* Zhongyan Chen*. Synthesis of 1-Aminoisoquinolines and Their Application in a Host-Guest Doped Strategy To Construct Ultralong RoomTemperature Phosphorescence Materials for Bioimaging, Chem. Eur. J. 2023, 29, e202202909.

文章链接：https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202202909

[7] Yaogeng Ma, Bingjie Guo, Jing-Yuan Ge,* Lepeng Chen, Ningning Lv, Xuan Wu,* Jiuxi Chen, Zhongyan Chen*. Rational Design of a Near-Infrared Ratiometric Probe with a Large Stokes Shift: Visualization of Polarity Abnormalities in Non-Alcoholic Fatty Liver Model Mice, Anal. Chem., 2022, 94, 12383-12390.

文章链接：https://pubs.acs.org/doi/10.1021/acs.analchem.2c01972

[6] Yetong Zhang, Wenzhang Xiong, Lepeng Chen, Yinlin Shao, Renhao Li, Zhongyan Chen,* Jingyuan Ge, Ningning Lv, Jiuxi Chen*. Palladium-catalyzed cascade reactions in aqueous media: synthesis and photophysical properties of pyrazino-fused quinazolinones, Org. Chem. Front., 2021, 8, 304-309.

文章链接：https://pubs.rsc.org/en/content/articlelanding/2021/qo/d0qo01244k

[5] Zhiwei Zhao, Ge Zeng, Yinan Chen, Jinming Zheng, Zhongyan Chen,* Yinlin Shao, Fangjun Zhang, Jiuxi Chen*, and Renhao Li* Palladium-Catalyzed Three-Component Cascade Reaction of Nitriles: Synthesis of 2-Arylquinoline-4-carboxylates, Org. Lett. 2021, 23, 7955-7960.

文章链接：https://pubs.acs.org/doi/10.1021/acs.orglett.1c02962

[4] Lepeng Chen, Shou-Feng Zhang, Zhongyan Chen,* Qianqian Zhen, Wenzhang Xiong, Yinlin Shao, Jing-Yuan Ge,* Ningning Lv, Jiuxi Chen*. Ni-catalyzed cascade coupling reactions: synthesis and thermally-activated delayed fluorescence characterization of quinazolinone derivatives, New J. Chem., 2021, 45, 20624-20628.

[3] Ling Dai, Shuling Yu, Wenzhang Xiong, Zhongyan Chen,* Tong Xu, Yinlin Shao, Jiuxi Chen*. Divergent Palladium-Catalyzed Tandem Reaction of Cyanomethyl Benzoates with Arylboronic Acids: Synthesis of Oxazoles and Isocoumarins, Adv. Synth. Catal. 2020, 362, 1893-1898.

[2] Jing-Yuan Ge,* Ya-Ru Qiu, Hai-Ying Wang, Jian Su, Peng Wang, Zhongyan Chen*. Magnetic Relaxation Dynamics of a Binuclear Diluted Er(III)/Y(III) Compound Influenced by Lattice Solvent, Chem. Asian J., 2020, 15, 3013-3019.

[1] Jing-Yuan Ge, Zhongyan Chen, Li Zhang, Xiao Liang, Jian Su, Mohamedally Kurmoo, Jing-Lin Zuo*. A Two-Dimensional Iron(II) Coordination Polymer with Synergetic Spin-Crossover and Luminescent Properties, Angew. Chem. Int. Ed., 2019, 58, 8789-8793.

欢迎感兴趣的研究生和本科生加入本小组学习和交流。