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何华成 博士
副教授,硕士生导师
应用化学系
  • 温州大学南校区11B-525F
    • · 创伤精准修复 · 生长因子的解密与临床转化 · 两性离子材料的开发

个人简介

BC015

主持项目:

  • 浙江省基础公益研究项目,2019/1-2021/12

  • 浙江省“钱江人才”项目,2019/1-2020/12

  • 国家自然科学青年基金项目,2018/01-2020/12

  • 温州市科技局项目,2018/01-2019/12

  • 浙江省教育厅项目,2017/10-2019/10


获奖和荣誉

2020年 温州大学伊利康青年学者

2018年 浙江省“钱江人才”

2018年 温州市“特支计划青年拔尖人才”

热忱欢迎感兴趣的化学、材料、医学、药学、生物学等相关本科生和研究生加入!


发表论文:

[37] Zhu, H.; Luo, H.; Lin, M.; Li, Y.; Chen, A., He, H.*; Sheng, F.; Wu, J.*, Methacrylated Gelatin Shape-memorable Cryogel Subcutaneously Delivers EPCs and aFGF for Improved Pressure Ulcer Repair in Diabetic Rat Model, Int. J. Bio. Macromol., 2022, Accepted. 

[36]  Tang, Z.#He, H.#; Zhu, L.; Liu, Z.; Yang, J.; Qin, G.; Wu, J.; Tang, Y.; Zhhang, D.; Chen, Q.*; Zheng, J.*, A General Protein Unfolding-Chemical Coupling Strategy for Pure Protein Hydrogels with Mechanically Strong and Multifunctional Properties, Adv. Sci., 2021, 2102557.


[35] Xu, J.; Xu, D.*; Xuan, X.*; He, H., Advances of Microneedles in Biomedical Applications. Molecules, 2021, 26, 5912. 


[34] Li, Y.#; Jiang, S.#; Song, L.; Yao, Z.;Zhang, J.; Wang, K.; Jiang, L.; He, H.*, Lin, C.*; Wu, J.* Zwitterionic Hydrogel Activates Autophagy to Promote Extracellular Matrix Remodeling for Improved Pressure Ulcer Healing. Front. Bioeng. Biotechnol., 2021, 9, 740863.

129F3


[33] Zhu, S.#; Ying, Y.#; Wu, Q.#; Ni, Z.; Huang, Z.; Cai, P.; Tu, Y.; Ying, W.; Ye, J.; Zhang, R.; Zhang, Y.; Chen, M.; Xiang, Z.; Dou, H.; Huang, Q.; Li, X.; He, H.*; Xiao, J.*; Ye, Q.*; Wang, Z*. Alginate self-adhesive hydrogel combined with dental pulp stem cells and FGF21 repairs hemisection spinal cord injury via apoptosis and autophagy mechanisms. Chem. Eng. J., 2021, 426, 130827

26C42


[32] Yang, Y.#; Zhang, Q.#; Zhang, J.; Chen, A.; Chen, Y.; Li, S.; Ye, M.; Xuan, X.; Li, X.; He, H.*; Wu, J.* Natural pollen extract for photothermal therapy. Mater. Design., 2021, 202, 109573.

F4F19


[31] Wu, J.#; Zhu, J.#; Wu, Q.#; An, Y.; Wang, K.; Xuan, T.; Zhang, J.; Song, W.; He, H.*; Song, L.; Zheng, J.*; Xiao, J.* Mussel-Inspired Surface Immobilization of Heparin on Magnetic Nanoparticles for Enhanced Wound Repair via Sustained Release of a Growth Factor and M2 Macrophage Polarization. ACS Appl. Mater. Interfaces, 2021, 13, 2230-2244.

6D10B


[30] Xiao, Z.#, Zheng, X.#, An, Y., Wang, K., Zhang, J., He, H.*, Wu, J.*, Zwitterionic hydrogel for sustained release of growth factors to enhance wound healing, Biomater. Sci., 2021, 9, 882-891.

99AE7


[29] Xiao, J#., Zhou, Y#., Ye, M., An, Y., Wang, K., Wu, Q., Song, L., Zhang, J., He, H.*, Zhang, Q., Wu, J.*, Freeze-Thawing Chitosan/Ions Hydrogel Coated Gauzes Releasing Multiple Metal Ions on Demand for Improved Infected Wound Healing, Adv. Healthcare. Mater., 2021, 2001591.  


[28] Li, S.#; Chen, A.#; Chen, Y.; Yang, Y.; Zhang, Q.; Luo, S.; Ye, M.; Zhou, Y.; An, Y.; Huang, W.; Xuan, T.; Pan, Y.; Xuan, X.; He, H.*; Wu, J.* Lotus Leaf Inspired Antiadhesive and Antibacterial Gauze for Enhanced Infected Dermal Wound Regeneration. Chem. Eng. J., 2020, 402, 126202.



[27]  Chen, Y.#; Ye, M.#; Song, L.; Zhang, J.; Yang, Y.; Luo, S.; Lin, M.; Zhang, Q.; Li, S.; Zhou, Y.; Chen, A.; An, Y.; Huang, W.; Xuan, T.; Gu, Y.; He, H.*; Wu, J.*; Li, X. Piezoelectric and Photothermal Dual Functional Film for Enhanced Dermal Wound Regeneration via Upregulation of Hsp90 and HIF-1α. Appl. Mater. Today2020, 20, 100756.


[26] Chen, A.#; An, Y.#; Huang, W.; Xuan, T.; Zhang, Q.; Ye, M.; Luo, S.; Xuan, X.; He, H.*; Zheng, J.*; Wu, J.* Highly Water-Preserving Zwitterionic Betaine-incorporated Collagen Sponges with Anti-oxidation and Anti-inflammation for Wound Regeneration. Front. Cell Dev. Biol.2020, 8, 491.



[25] Chen, A.; Huang, W.; Wu, L.; An, Y.; Xuan, T.; He, H.*; Ye, M.; Qi, L.; Wu, J. Bioactive ECM Mimic Hyaluronic Acid Dressing via Sustained Releasing of bFGF for Enhancing Skin Wound Healing. ACS Appl. Bio Mater., 2020, 3, 3039-3048.

17612

 

[24] Hu, J.; Song, Y.; Zhang, C.; Huang, W.; Chen, A.; He, H.*; Zhang, S.; Chen, Y.; Tu, C.; Liu, J.; Xuan, X.; Chang, Y.; Zheng, J.; Wu, J. Highly Aligned Electrospun Collagen/Polycaprolactone Surgical Sutures with Sustained Release of Growth Factors for Wound Regeneration. ACS Appl. Bio Mater., 2020, 3, 965-976.

1C65A  

[23] Xuan, X.; Zhou, Y.; Chen, A.; Zheng, S.; An, Y.; He, H.*; Huang, W.; Chen, Y.; Yang, Y.; Li, S.; Xuan, T.; Xiao, J.; Li, X.; Wu, J*. Silver crosslinked injectable bFGF-eluting supramolecular hydrogels speed up infected wound healing. J. Mater. Chem. B, 2020, 8, 1359-1370. Cover Page


[22] He, H.; Nieminen, A.-L.; Xu, P.* Bioactivatable Self-quenched Nanogel for Targeted Photodynamic Therapy. Biomater. Sci., 2019,7, 5143-5149.

451BF

 

[21] Wu, J.; Chen, A.; Zhou, Y.; Zheng, S.; Yang, Y.; An, Y.; Xu, K.; He, H.*; Kang, J.; Luckanagul, J. A.; Xian, M.; Xiao, J.*; Wang, Q.* Novel H2S-Releasing hydrogel for wound repair via in situ polarization of M2 macrophages. Biomaterials, 2019, 222, 119398.

  2909A

[20] Li, Y.; Xiao, Z.; Zhou, Y.; Zheng, S.; An, Y.; Huang, W.; He, H.*; Yang, Y.; Li, S.; Chen, Y.; Xiao, J.*; Wu, J.* Controlling the Multiscale Network Structure of Fibers To Stimulate Wound Matrix Rebuilding by Fibroblast Differentiation. ACS Appl. Mater. Interfaces, 2019, 11, 28377-28386. 

2E4C3


[19] He, H.; Xiao, Z.; Zhou, Y.; Chen, A.; Xuan, X.; Li, Y.; Guo, X.; Zheng, J.*; Xiao, J.*; Wu, J.* Zwitterionic poly(sulfobetaine methacrylate) hydrogels with optimal mechanical properties for improving wound healing in vivo. J. Mater. Chem. B, 2019, 7, 1697-1707Cover Page

[18] Zheng, Z.; Chen, A.; He, H.*; Chen, Y.; Chen, J.; Albashari, A. A.; Li, J.; Yin, J.; He, Z.; Wang, Q.; Wu, J.; Wang, Q.; Kang, J.; Xian, M.; Wang, X.*; Xiao, J.* pH and enzyme dual-responsive release of hydrogen sulfide for disc degeneration therapy. J. Mater. Chem. B, 20197, 611-618.

[17] He, H.; Xuan, X.; Zhang, C.; Song, Y.; Chen, S.; Gong, X.; Ren, B.; Zheng, J.*; Wu, J.* Simple Thermal Pretreatment Strategy to Tune Mechanical and Antifouling Properties of Zwitterionic Hydrogels. Langmuir, 201935, 1828-1836.


[16] Ye, Q.; Wu, Y.; Wu, J.; Zou, S.; Al-Zaazaai, A. A.; Zhang, H.; Shi, H.; Xie, L.; Liu, Y.; Xu, K.; He, H.; Zhang, F.; Ji, Y.; He, Y.; Xiao, J.* Neural Stem Cells Expressing bFGF Reduce Brain Damage and Restore Sensorimotor Function after Neonatal Hypoxia-Ischemia. Cell Physiol. Biochem, 2018, 45, 108-118.

[15] Wu, J.; Xiao, Z.; Chen, A.; He, H.*; He, C.; Shuai, X.; Li, X.; Chen, S.; Zhang, Y.; Ren, B.; Zheng, J.*; Xiao, J.* Sulfated zwitterionic poly(sulfobetaine methacrylate) hydrogels promote complete skin regeneration. Acta Biomater., 2018, 71, 293-305.

[14] Wang, Q.; Cai, H.; Hu, Z.; Wu, Y.; Guo, X.; Li, J.; Wang, H.; Liu, Y.; Liu, Y.; Xie, L.; Xu, K.; Xu, H.; He, H.*; Zhang, H.; Xiao, J.* Loureirin B promotes axon regeneration by inhibiting ER stress-induced mitochondrial dysfunction and regulating the Akt/GSK-3β pathway after spinal cord injury. J. Neurotraum., 2018, 5966.

[13] Wang, H.; Wu, Y.; Han, W.; Li, J.; Xu, K.; Li, Z.; Wang, Q.; Xu, K.; Liu, Y.; Xie, L.; Wu, J.; He, H.; Xu, H.; Xiao, J.* Hydrogen sulfide ameliorates blood-spinal cord barrier disruption and improves functional recovery by inhibiting endoplasmic reticulum stress-dependent autophagy. Front. Pharmacol., 2018, 9, 1-16.

[12] He, H.; Markoutsa, E.; Li, J.; Xu, P.* Repurposing disulfiram for cancer therapy via targeted nanotechnology through enhanced tumor mass penetration and disassembly. Acta Biomater., 201868, 113-124.

[11] He, H.; Hashemi, L.; Hu, M.-L.*; Morsali, A.* The role of the counter-ion in metal-organic frameworks’ chemistry and applications. Coordin. Chem. Rev., 2018376, 319-347.

[10] Chen, A.; He, H.*; Ma, G.; Li, Y.; Jiang, S.; Xuan, X.; Song, Y.; Zhang, C.; Xiao, J.; Xu, Y.; Wu, J.*; Chen, S. Biodegradable copolypeptide hydrogel prodrug accelerates dermal wound regeneration by enhanced angiogenesis and epithelialization. RSC Adv., 20188, 10620-10626.

[9] Wu, J.; He, C.; He, H.*; Cheng, C.; Zhu, J.; Xiao, Z.; Zhang, H.; Li, X.; Zheng, J.*; Xiao, J.* Importance of zwitterionic incorporation into polymethacrylate-based hydrogels for simultaneously improving optical transparency, oxygen permeability, and antifouling properties. J. Mater. Chem. B, 20175, 4595-4606. 


[8] Li, R.; Zou, S.; Wu, Y.; Li, Y.; Khor, S.; Mao, Y.; He, H.; Xu, K.; Zhang, H.; Li, X.; Wang, J.; Jiang, H.; Jin, Q.; Ye, Q.; Wang, Z.; Xiao, J.* Heparin-based coacervate of bFGF facilitates peripheral nerve regeneration by inhibiting endoplasmic reticulum stress following sciatic nerve injury. Oncotarget, 2017, 1-13. 


[7] He, Z.; Zou, S.; Yin, J.; Gao, Z.; Liu, Y.; Wu, Y.; He, H.; Zhou, Y.; Wang, Q.; Li, J.; Wu, F.; Xu, H. Z.; Jia, X.; Xiao, J.* Inhibition of Endoplasmic Reticulum Stress Preserves the Integrity of Blood-Spinal Cord Barrier in Diabetic Rats Subjected to Spinal Cord Injury. Sci. Rep., 20177, 1-14.

[6] He, Z.; Zhou, Y.; Huang, Y.; Wang, Q.; Zheng, B.; Zhang, H.; Li, J.; Liu, Y.; Wu, F.; Zhang, X.; Tong, S.; Wang, M.; Wang, Z.; He, H.; Xu, H.; Xiao, J.* Dl-3-n-butylphthalide improves functional recovery in rats with spinal cord injury by inhibiting endoplasmic reticulum stress-induced apoptosis. American Journal of Translational Research, 20179, 1075-1087.

[5] He, H.; Markoutsa, E.; Zhan, Y.; Zhang, J.; Xu, P. Mussel-inspired PLGA/polydopamine core-shell nanoparticle for light induced cancer thermochemotherapy. Acta Biomater., 201759, 181-191.

[4] He, H.; Altomare, D.; Ozer, U.; Xu, H.; Creek, K.; Chen, H.; Xu, P.* Cancer cell-selective killing polymer/copper combination. Biomater. Sci., 20164, 115-120.

[3] Cheng, B.; He, H.; Huang, T.; Berr, S. S.; He, J.; Fan, D.; Zhang, J.; Xu, P.* Gold nanosphere gated mesoporous silica nanoparticle responsive to near-infrared light and redox potential as a theranostic platform for cancer therapy. Journal of Biomedical Nanotechnology, 201612, 435-449.

[2] He, H.; Cattran, A. W.; Nguyen, T.; Nieminen, A. L.; Xu, P.* Triple-responsive expansile nanogel for tumor and mitochondria targeted photosensitizer delivery. Biomaterials, 201435, 9546-9553.

[1] Cao, Z.; Chen, F.; Bao, N.; He, H.; Xu, P.; Jana, S.; Jung, S.; Lian, H.; Lu, C. Droplet sorting based on the number of encapsulated particles using a solenoid valve. Lab on a Chip, 201313, 171-178.